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KMID : 0379120170450040336
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Korean Journal of Mycology
2017 Volume.45 No. 4 p.336 ~ p.344
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Anti-inflammatory Activity of Wild Yeasts, Meyerozyma guilliermondii YJ34-2 and Rhodotorula graminis YJ36-1, on Lipopolysaccharide-induced Nitric Oxide in RAW 264.7 Cells Through the Inhibition of Nitric Oxide and Cytotoxic Effects
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Bae Sang-Min
Han Sang-Min
Lee Jong-Soo
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Abstract
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The anti-inflammatory effects of cell-free extracts from wild yeasts, YJ34-2 and YJ36-1, caused by the inhibition of nitric oxide (NO) activity and cytotoxic effects were determined. Cell-free extracts from these two yeast strains had dose-dependent inhibitory effects on the production of lipopolysaccharide-induced NO and there were no cytotoxic effects on the treated cells or negative effects on their proliferation. Their cell-free extracts were also shown to have inhibitory effects on pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α and prostaglandin-E2, in a dose-dependent manner. Maximal inhibitory activity on NO production occurred in cell-free extracts of Meyerozyma guilliermondii YJ34-2 cultivated at 30°C for 24 hr and YJ36-1 cultivated at 25°C for 24 hr in the yeast extract-peptone-dextrose (YPD) media.
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KEYWORD
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Anti-inflammatory effects, Lipopolysaccharide-induced nitric oxide, RAW 264.7 cells, Meyerozyma guilliermondii YJ34-2, Rhodotorula graminis YJ36-1
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